— Men's Health
The Link Between Low Testosterone, Anxiety and Depression
Medically reviewed by Dr. Brandon Mines, MD
Low testosterone affects emotional health, not just the body — it’s linked to higher rates of anxiety and depression in men. One 2016 study found low serum testosterone was associated with an 86% increased risk of depression in older men, underscoring that mood and hormones are deeply connected.
The brain-chemistry connection
Testosterone helps regulate the neurotransmitters that govern mood, especially serotonin and dopamine. When testosterone drops, serotonin production can fall too — mirroring patterns seen in clinical depression — while reduced dopamine signaling can blunt motivation and pleasure. Physical symptoms like fatigue, weight gain and sexual dysfunction often compound the emotional toll.
Where therapy fits in
Testosterone replacement therapy is not a replacement for mental health treatment, but for men with a confirmed deficiency it may support mood — some research notes it can influence serotonin activity in ways comparable to SSRIs. Many men on TRT report improved mood, less anxiety and a brighter outlook. Persistent depression or anxiety always warrants a full evaluation with a qualified provider.
Talk to a physician
Bubolo Medical has supported men’s health since 2001 from clinics in Acworth and Marietta, with virtual care across Georgia. A consultation and labs can show whether low testosterone is contributing to how you feel.