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Hypothyroidism, brought into focus.

An underactive thyroid can quietly drain your energy, slow your metabolism, and cloud your mood. Here is what hypothyroidism is, why it happens, and when a simple blood test is worth it.

Medically reviewed by Dr. Brandon Mines, MDLast reviewed May 1, 2026

What is hypothyroidism?

Hypothyroidism, or underactive thyroid, is a condition in which the thyroid gland does not produce enough thyroid hormone. The thyroid, a small butterfly-shaped gland in the neck, helps regulate metabolism, so a shortage slows many of the body’s processes.

Because thyroid hormone touches nearly every system, the symptoms are wide-ranging and often subtle — fatigue, weight gain, cold sensitivity, and low mood among them. They tend to develop gradually, which is why hypothyroidism can go unrecognized for some time.

Hypothyroidism is diagnosed with blood tests, typically TSH and sometimes free T4, rather than symptoms alone. It is a common and very treatable condition; most people manage it well with daily thyroid hormone replacement and periodic monitoring.

Symptoms

Signs to watch for.

  • Persistent fatigue and sluggishness
  • Unexplained weight gain or difficulty losing weight
  • Increased sensitivity to cold
  • Dry skin and thinning or brittle hair
  • Constipation
  • Depressed mood or difficulty concentrating
  • Muscle aches, stiffness, or weakness
  • Slowed heart rate
  • Heavier or irregular menstrual periods

Causes

What's behind it.

  • Hashimoto’s thyroiditis, an autoimmune condition and the most common cause
  • Surgical removal of part or all of the thyroid gland
  • Radiation therapy to the neck or radioactive iodine treatment
  • Certain medications that affect thyroid function
  • Iodine deficiency or, in some cases, excess
  • A problem with the pituitary gland (less common, secondary hypothyroidism)
  • Thyroid changes that can occur after pregnancy

When to see a physician.

  • If you have ongoing fatigue, unexplained weight gain, or cold sensitivity that does not improve
  • If you have a family history of thyroid or autoimmune disease and develop symptoms
  • If you are already on thyroid medication and notice your symptoms returning or changing — your dose may need adjustment

Common Questions

About hypothyroidism.

01How is hypothyroidism diagnosed?

It is diagnosed with blood tests, most commonly TSH and sometimes free T4, rather than symptoms alone. An elevated TSH typically points to an underactive thyroid. A physician interprets the results in the context of your symptoms and history.

02Is hypothyroidism permanent?

Often it is a lifelong condition managed with daily medication, though some cases — such as those triggered by pregnancy or certain medications — can be temporary. Either way, it is highly treatable with proper monitoring.

03Can hypothyroidism cause weight gain?

Because thyroid hormone helps regulate metabolism, an underactive thyroid can contribute to weight gain and difficulty losing weight. Treating the deficiency may help, but thyroid issues are usually one factor among several worth evaluating.

04What happens if hypothyroidism goes untreated?

Untreated hypothyroidism can worsen symptoms over time and, in some cases, contribute to high cholesterol, heart problems, and other complications. This is why testing and ongoing management matter — talk to a physician if you have symptoms.

Begin better.

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